Comprehensive List of Canine Genetic Markers

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The Basepaws Canine Baseline DNA Health + Breed test provides your veterinary team with valuable insights by revealing hundreds of markers associated with known genetic diseases.  Below you will find a list of the DNA health markers included in the Basepaws Canine Baseline test.

If you have a question about a specific marker, please contact us.



Disease Gene Markers per Condition
cardiomyopathy and juvenile mortality YARS2 1
cardiomyopathy, dilated RBM20 1
dilated cardiomyopathy TTN 1


Disease Gene Markers per Condition
anhidrotic ectodermal dysplasia EDA 1
darier disease ATP2A2 1
epidermolysis bullosa, dystrophic COL7A1 2
epidermolysis bullosa, junctionalis, lama3-related LAMA3 1
epidermolysis bullosa, junctionalis, lamb3-related LAMB3 1
epidermolysis bullosa, simplex, plec PLEC 1
exfoliative cutaneous lupus erythematosus UNC93B1 1
hyperkeratosis, epidermolytic KRT10 1
hyperkeratosis, palmoplantar, fam83g-related FAM83G 1
hyperkeratosis, palmoplantar, dsg1-related DSG1 1
ichthyosis, TGM1-related TGM1 1
ichthyosis, pnpla1-related PNPLA1 1
ichthyosis, slc27a4-related SLC27A4 1
nasal parakeratosis SUV39H2 1
verrucous epidermal keratinocytic nevi NSDHL 2


Disease Gene Markers per Condition
dwarfism, growth-hormone deficiency GH1 1
hypothyroidism with or without goiter TPO 2
pituitary dwarfism LHX3 1


Disease Gene Markers per Condition
familial adenomatous polyposis APC 1
intestinal cobalamin malabsorption, cubn-related CUBN 2
lundehund syndrome LEPREL1 1
wilson disease ATP7B 1


Disease Gene Markers per Condition
bleeding disorder, p2ry12-related P2RY12 1
deficiency of platelet receptor for factor x ANO6 1
elliptocytosis SPTB 1
factor vii deficiency F7 1
factor xi deficiency F11 1
haemophilia a F8 4
haemophilia b F9 5
ligneous membranitis PLG 1
may-hegglin anomaly MYH9 1
methemoglobinaemia, cyb5r3-related CYB5R3 2
polycythemia JAK2 1
prekallikrein deficiency KLKB1 1
pyruvate kinase deficiency of erythrocyte, HCN3-related HCN3 4
thrombasthenia ITGA2B 2
thrombopathia, RASGRP2-related RASGRP2 2
thrombopathia, RASGRP1-related RASGRP1 1
von willebrand disease i VWF 1
von willebrand disease ii VWF 2
von willebrand disease iii VWF 3


Disease Gene Markers per Condition
c3 deficiency C3 1
leukocyte adhesion deficiency, type I ITGB2 1
leukocyte adhesion deficiency, type iii FERMT3 1
leukodystrophy, tsen54-related TSEN54 1
severe combined immunodeficiency disease, autosomal PRKDC 1
severe combined immunodeficiency disease, autosomal, t cell-negative, b cell-negative, nk cell-positive RAG1 1
severe combined immunodeficiency disease, x-linked IL2RG 2
trapped neutrophil syndrome VPS13B 1


Disease Gene Markers per Condition
beta mannosidosis MANBA 1
ciliary dyskinesia, primary, CCDC39-related CCDC39 1
ciliary dyskinesia, primary, nme5-related NME5 1
exercise induced metabolic myopathy ACADVL 1
exercise-induced collapse DNM1 1
fucosidosis, alpha FUCA1 1
gangliosidosis, gm1 GLB1 3
gangliosidosis, gm2, type i HEXA 1
gangliosidosis, gm2, type ii (sandhoff or variant 0) HEXB 2
glycogen storage disease ii GAA 1
glycogen storage disease iiia AGL 1
glycogen storage disease vii PFKM 2
hypocatalasia CAT 1
menkes disease ATP7A 1
mucopolysaccharidosis iiia SGSH 2
mucopolysaccharidosis vi ARSB 2
mucopolysaccharidosis vii GUSB 2
neuronal ceroid lipofuscinosis, 1 PPT1 1
neuronal ceroid lipofuscinosis, 10 CTSD 1
neuronal ceroid lipofuscinosis, 12 ATP13A2 1
neuronal ceroid lipofuscinosis, 2 TPP1 1
neuronal ceroid lipofuscinosis, 4a ARSG 1
neuronal ceroid lipofuscinosis, 6 CLN6 1
neuronal ceroid lipofuscinosis, 8 CLN8 3
pyruvate dehydrogenase deficiency PDP1 1
pyruvate kinase deficiency of erythrocyte, PKLR-related PKLR 1
succinic semialdehyde dehydrogenase deficiency ALDH5A1 1

Musculoskeletal and Connective Tissue

Disease Gene Markers per Condition
chondrodysplasia, disproportionate short-limbed ITGA10 1
craniomandibular osteopathy SLC37A2 1
ehlers-danlos syndrome, classic type, 1 COL5A1 2
ehlers-danlos syndrome, type vii (dermatosparaxis) ADAMTS2 1
hypophosphatasia ALPL 1
inflammatory myopathy, slc25a12-related SLC25A12 1
muscular dystrophy, col6a3-related COL6A3 2
muscular dystrophy, duchenne DMD 1
muscular dystrophy, limb-girdle, type r3 SGCA 1
muscular hypertrophy (double muscling) MSTN 1
musladin-lueke syndrome ADAMTSL2 1
myopathy, great dane BIN1 1
myotonia CLCN1 4
myotubular myopathy 1 MTM1 2
oculoskeletal dysplasia 1 COL9A3 1
osteogenesis imperfecta_dachshund SERPINH1 1
osteogenesis imperfecta, col1a2-related COL1A2 3
osteogenesis imperfecta, type iii, col1a1-related COL1A1 1
skeletal dysplasia 2 (sd2) COL11A2 1
spondylocostal dysostosis HES7 1


Disease Gene Markers per Condition
alexander disease GFAP 1
ataxia, cerebellar, atp1b2-related ATP1B2 1
ataxia, cerebellar, in old english sheepdogs and gordon setters RAB24 1
ataxia, cerebellar, kcnj10-related KCNJ11 1
ataxia, spinocerebellar, CAPN1-related CAPN1 1
ataxia, spinocerebellar, scn8a-related SCN8A 1
ataxia, spinocerebellar, sptbn2-related SPTBN2 1
Congenital Myasthenic Syndrome (Labrador Retriever Type) COLQ 1
degenerative myelopathy SOD1 1
epilepsy, benign familial juvenile LGI2 1
epilepsy, generalized myoclonic, with photosensitivity DIRAS1 1
epilepsy, mitochondrial dysfunction and neurodegeneration PITRM1 1
krabbe disease GALC 1
l-2-hydroxyglutaricacidemia L2HGDH 2
leucodystrophy CYTB 1
leukoencephalomyelopathy NAPEPLD 2
Reduced ability to metabolize cognitive enhancer 5-(3-methoxyphenyl)-3-(5-methyl1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine (AC-3933) CYP1A2 1
myasthenic syndrome, congenital, chat-related CHAT 1
myasthenic syndrome, congenital, chrne-related CHRNE 2
narcolepsy HCRTR2 2
necrotising encephalopathy, subacute, of leigh SLC19A3 1
neonatal encephalopathy with seizures ATF2 1
neuroaxonal dystrophy, juvenile TECPR2 1
neuroaxonal dystrophy, pla2g6-related PLA2G6 1
neuroaxonal dystrophy, vps11-related VPS11 1
neurodegenerative vacuolar storage disease ATG4D 1
neuropathy, sensory RETREG1 1
neuropathy, sensory ataxic MT-TY 1
polyneuropathy NDRG1 2
polyneuropathy (lpn2) GJA9 1
polyneuropathy, ocular abnormalities and neuronal vacuolation RAB3GAP1 1
polyneuropathy, sbf2-related SBF2 1
spongy degeneration with cerebellar ataxia 1 (sdca1) KCNJ12 1
tremor, x-linked PLP1 1


Disease Gene Markers per Condition
achromatopsia (cone degeneration, hemeralopia), gspt CNGB3 1
achromatopsia-2 CNGA3 2
autosomal dominant pra RHO 1
cone-rod dystrophy 1 PDE6B 1
congenital keratoconjunctivitis sicca and ichthyosiform dermatosis FAM83H 1
early retinal degeneration STK38L 1
eye malformation, congenital SIX6 1
generalized pra CCDC66 1
Glaucoma (Border Collie Type) OLFML3 1
glaucoma, primary open angle, adamts10-related ADAMTS10 2
glaucoma, primary open angle, adamts17-related ADAMTS17 1
golden retriever pra 1 SLC4A3 1
golden retriever pra 2 TTC8 1
leber congenital amaurosis (congenital stationary night blindness) RPE65 1
lens luxation ADAMTS17 1
macular corneal dystrophy CHST6 1
microphthalmia, isolated, with coloboma RBP4 1
multifocal retinopathy 1 BEST1 1
multifocal retinopathy 2 BEST1 1
multifocal retinopathy 3 BEST1 1
night blindness, congenital stationary, lrit3-related LRIT3 1
Primary open-angle glaucoma (POAG), primary lens luxation (PLL), or both ADAMTS17 1
progressive retinal atrophy IFT122 1
progressive retinal atrophy CNGB1 1
progressive retinal atrophy, basenji SAG 1
progressive retinal atrophy, due to cnga1 mutations CNGA1 1
progressive retinal atrophy, miniature schnauzer, type 1 HIVEP3 1
progressive retinal atrophy, necap1-related NECAP1 1
progressive rod-cone degeneration PRCD 1
rod-cone dysplasia 1 PDE6B 1
rod-cone dysplasia 3 PDE6A 1
stargardt disease 1 ABCA4 1

Other Systems

Disease Gene Markers per Condition
adverse reaction to certain drugs (MDR1) ABCB1 1
amelogenesis imperfecta ENAM 1
brachycephaly BMP3 1
deafness, bilateral, and vestibular dysfunction MYO7A 1
dental hypomineralization FAM20C 1
decreased litter size GDF9 1
nonsyndromic hearing loss LOXHD1 1
obesity POMC 1
periodic fever syndrome MTBP 1
persistent mullerian duct syndrome AMHR2 1


Disease Gene Markers per Condition
cystinuria, type i - a SLC3A1 1
cystinuria, type ii - a SLC3A1 1
cystinuria, type ii - b SLC7A9 2
diffuse cystic renal dysplasia and hepatic fibrosis INPP5E 1
nephritis, x-linked COL4A5 1
nephropathy COL4A4 2
polycystic kidney disease PKD1 1
primary hyperoxaluria type i (oxalosis i) AGXT 1
Protein Losing Nephropathy, KIRREL2-related KIRREL2 1
Protein Losing Nephropathy, NPHS1-related NPHS1 1
renal cystadenocarcinoma and nodular dermatofibrosis FLCN 1
urolithiasis SLC2A9 1
urolithiasis (Native American Indian Dog Type) APRT 1


Disease Gene Markers per Condition
recurrent inflammatory pulmonary disease AKNA 1
surfactant metabolism dysfunction, pulmonary LAMP3 1

Questions about genetic markers?

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If you have a specific question about a genetic marker included in our report, or would like to find out why one is not included, please contact us!


Decode your canine patients' health risks

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Basepaws Veterinary Canine Baseline DNA Health + Breed test uses innovative and modern sequencing methods, including Next-Gen sequencing and low-pass whole genome sequencing to get a clearer picture of potential genetic mutations and copies of mutations that are associated with disease risk.